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Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* fever, chills, body aches, flu symptoms;
* white patches or sores inside your mouth or on your lips; or
* feeling like you might pass out.

Less serious side effects include:

* drowsiness, dizziness, weakness;
* nausea, stomach pain;
* constipation;
* increased appetite, weight gain;
* dry mouth; or
* thirst.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Get emergency help immediately if any of the following symptoms of overdose occur:

Agitation; confusion; convulsions (seizures); decreased reflexes; extreme drowsiness; high blood pressure; loss of memory; nausea; slurred speech; vomiting

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

More common

Dryness of mouth; trembling or shaking of arms or legs

Less common or rare

Abdominal or stomach pain or discomfort; change in your sense of taste; constipation; diarrhea; dizziness; drowsiness; feeling of warmth of the face, neck, arms, and occasionally upper chest; heartburn or indigestion; increased or decreased appetite; increased sweating; joint or muscle pain; nightmares; trouble sleeping.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

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Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and check with your doctor immediately if any combination of the following side effects occur:

Fast or racing heartbeat; pounding or irregular heartbeat; neck stiffness; severe throbbing headache which starts at the back of the head and radiates forward; slow heartbeat. Check with your doctor as soon as possible if any of the following side effects occur:

More common

Mild to moderate headache, or pressure in head

Less common

Anxiety; blurred vision or other changes in vision; dizziness, faintness, or lightheadedness, especially when getting up from a sitting or lying position; fast or racing heartbeat; high blood pressure; irritability; nervousness; pounding or irregular heartbeat; restlessness; unusual tiredness or weakness

Rare

Aggressive behavior; bleeding gums; burning, prickling, or tingling sensations; chest pain ; confusion; increased depression, or other mood and mental changes; difficulty in speaking; fast, slow, or irregular heart beat; feeling of something in the eye; general feeling of illness; headache (severe); increase in urination; increased sensitivity of eyes to light; irregular or prolonged menstrual periods; irritation or soreness of mouth; itching, redness, and swelling of eye; loss of balance control; loss of interest in self or surroundings; memory problems; pain or straining to pass urine or stool; painful urination; restlessness or desire to keep moving; ringing or noise in ears; seeing, hearing, or feeling something things that are not there; skin rash, hives, or itching; stomach pain or burning; slow heartbeat; troubled breathing; twisting movements of body; uncontrolled movements, especially of face, neck, and back

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Avoid drinking alcohol, which can increase some of the side effects of Effexor. Effexor can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with Effexor may cause you to bruise or bleed easily.

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Stop taking Desyrel and call your doctor at once if you have a penis erection that is painful or lasts 4 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* feeling light-headed, fainting;
* fever, chills, body aches, flu symptoms; or
* chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
* problems with urination.

Less serious side effects may be more likely to occur, such as:

* dizziness or drowsiness;
* headache;
* sleep problems (insomnia);
* dry mouth, stuffy nose;
* nausea, vomiting, loss of appetite;
* diarrhea or constipation;
* muscle pain;
* loss of coordination; or
* blurred vision.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with Cymbalta may cause you to bruise or bleed easily.

Before taking Cymbalta, tell your doctor if you are using any of the following medicines:

* a blood thinner such as warfarin (Coumadin);
* cimetidine (Tagamet);
* a diuretic (water pill);
* fluvoxamine (Luvox);
* linezolid (Zyvox);
* lithium (Lithobid, Eskalith);
* St. John’s wort;
* tramadol (Ultram);
* tryptophan (sometimes called L-tryptophan);
* an antibiotic such as ciprofloxacin (Cipro) or enoxacin (Penetrex);
* almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig);
* aspirin or an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others;
* any other antidepressant such as desipramine (Norpramin), fluoxetine (Prozac, Sarafem), paroxetine (Paxil), and others.

This list is not complete and there may be other drugs that can interact with Cymbalta. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
* restlessness, overactive reflexes, hallucinations, loss of coordination, fainting, coma;
* nausea, vomiting, diarrhea, fever, and fast heartbeat;
* painful or difficult urination;
*  easy bruising or bleeding, nosebleeds, or
* black, bloody, or tarry stools.

Less serious side effects may include:

* dry mouth;
* drowsiness, dizziness, headache;
* diarrhea, constipation;
* sleep problems (insomnia);
* weight changes;
* feeling anxious or nervous, increased sweating; or
* decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Avoid drinking alcohol while taking Cymbalta. Alcohol may increase the risk of damage to your liver. Cymbalta can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety). They can add to sleepiness caused by Cymbalta.

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Seek emergency medical attention if you think you have taken too much of this medication. Overdose symptoms may include nausea, vomiting, diarrhea, agitation, confusion, hallucinations, fast heart rate, feeling light-headed, or fainting.

Cymbalta missed dose

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

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Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from the medication.

Try to take the medicine at the same time each day. Follow the directions on your prescription label.
Do not crush, chew, break, or open a delayed-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. It may take 4 weeks or longer for your symptoms to improve. For best results, keep using the medication as directed. Do not stop using Cymbalta without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly.

Store Cymbalta at room temperature away from moisture and heat.

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