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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

* fever;
* feeling short of breath, even with mild exertion;
* swelling, rapid weight gain;
* problems with hearing;
* numbness or tingly feeling;
* pain or burning when you urinate; or
* nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

* diarrhea, constipation, mild stomach pain;
* mild itching or skin rash;
* headache, dizziness; or
* runny nose or other cold symptoms.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and check with your doctor immediately if any combination of the following side effects occur:

Fast or racing heartbeat; pounding or irregular heartbeat; neck stiffness; severe throbbing headache which starts at the back of the head and radiates forward; slow heartbeat. Check with your doctor as soon as possible if any of the following side effects occur:

More common

Mild to moderate headache, or pressure in head

Less common

Anxiety; blurred vision or other changes in vision; dizziness, faintness, or lightheadedness, especially when getting up from a sitting or lying position; fast or racing heartbeat; high blood pressure; irritability; nervousness; pounding or irregular heartbeat; restlessness; unusual tiredness or weakness

Rare

Aggressive behavior; bleeding gums; burning, prickling, or tingling sensations; chest pain ; confusion; increased depression, or other mood and mental changes; difficulty in speaking; fast, slow, or irregular heart beat; feeling of something in the eye; general feeling of illness; headache (severe); increase in urination; increased sensitivity of eyes to light; irregular or prolonged menstrual periods; irritation or soreness of mouth; itching, redness, and swelling of eye; loss of balance control; loss of interest in self or surroundings; memory problems; pain or straining to pass urine or stool; painful urination; restlessness or desire to keep moving; ringing or noise in ears; seeing, hearing, or feeling something things that are not there; skin rash, hives, or itching; stomach pain or burning; slow heartbeat; troubled breathing; twisting movements of body; uncontrolled movements, especially of face, neck, and back

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Do not take Pheniramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking Pheniramine without first talking to your doctor or pharmacist. Other medications may also contain pheniramine, pyrilamine, phenyltoloxamine, phenylpropanolamine, or other similar drugs. You may accidentally take too much of these medicines.

Pheniramine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if Pheniramine is taken with any of these medications.

Drugs other than those listed here may also interact with Pheniramine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

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Serious side effects are unlikely to occur. Stop taking Pheniramine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take Pheniramine and talk to your doctor or try another similar medication if you experience

* dryness of the eyes, nose, and mouth;
* drowsiness or dizziness;
* blurred vision;
* difficulty urinating; or
* excitation in children.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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Use caution when driving, operating machinery, or performing other hazardous activities. Pheniramine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking Pheniramine.

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Seek emergency medical attention. Symptoms of a Pheniramine overdose include a dry mouth, large pupils, flushing, nausea, and vomiting.

Pheniramine missed dose

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

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Take Pheniramine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Do not crush, chew, or break the long-acting or sustained-release forms of this medication. Swallow them whole. If you are unsure about the formulation of the medicine, ask your pharmacist for help.

If you cannot swallow the tablets or capsules, look for a liquid form of this medication.

To ensure that you get a correct dose, measure the liquid form of Pheniramine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one. Do not take more of this medication than is recommended. An overdose can cause serious harm.

Do not take Pheniramine for longer than 7 days in a row. If your symptoms do not improve, if they get worse, or if you have a fever, talk to your doctor.

Store Pheniramine at room temperature away from moisture and heat.

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Do not take Pheniramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

* kidney disease,
* liver disease,
* diabetes,
* glaucoma,
* any type of heart disease or high blood pressure,
* thyroid disease,
* emphysema or chronic bronchitis, or
* difficulty urinating or an enlarged prostate.

You may not be able to take Pheniramine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Pheniramine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Pheniramine passes into breast milk and may harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from Pheniramine. You may require a lower dose of this medication. Read the package label for directions or consult your doctor or pharmacist before treating a child with this medication. Children are more susceptible than adults to the effects of medicines and may have unusual reactions.

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Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Use caution when driving, operating machinery, or performing other hazardous activities. Pheniramine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking this medication.

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.

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Generic Name: pheniramine (fen IR a meen/pie RILL a meen)

What is Pheniramine?

Pheniramine, pyrilamine, and phenyltoloxamine are antihistamines. They block the effects of the naturally occurring chemical histamine in the body. Pheniramine, pyrilamine, and phenyltoloxamine prevent sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow to certain areas and allows nasal and respiratory (breathing) passages to open up.

Pheniramine is used to treat nasal congestion and sinusitis (inflammation of the sinuses) associated with allergies, hay fever, and the common cold.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Pheniramine may also be used for purposes other than those listed in this medication guide.

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