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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* fast, pounding, or uneven heart rate;
* confusion, hallucinations, or seizure (convulsions);
* easy bruising or bleeding, unusual weakness;
* feeling light-headed, fainting;
* restless muscle movements in your eyes, tongue, jaw, or neck;
* tremors or uncontrollable shaking;
* urinating less than usual or not at all; or
* extreme thirst with headache, nausea, vomiting, and weakness.

Less serious side effects may include:

* nausea, vomiting, constipation, loss of appetite;
* dry mouth;
* weight changes;
* weakness, lack of coordination;
* numbness or tingly feeling;
* feeling dizzy, drowsy, or tired;
* sleep problems (insomnia), nightmares;
* blurred vision, headache, ringing in your ears;
* increased sweating;
* breast swelling (in men or women); or
* decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse: mood changes, anxiety, panic attacks, trouble sleeping, irritability, agitation, aggressiveness, severe restlessness, mania (mental and/or physical hyperactivity), thoughts of suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* seizure (convulsions);
* tremors, shivering, muscle stiffness or twitching;
* problems with balance or coordination;
* agitation, confusion, sweating, fast heartbeat; or
* easy bruising or bleeding (such as a nosebleed).

Less serious side effects may include:

* feeling nervous, restless, or unable to sit still;
* drowsiness, dizziness, weakness;
* sleep problems (insomnia);
* nausea, constipation, loss of appetite;
*  weight changes;
* decreased sex drive, impotence, or difficulty having an orgasm; or
* dry mouth, yawning, or ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Do not use Paxil if you are using pimozide (Orap), thioridazine (Mellaril), or an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam). Serious and sometimes fatal reactions can occur when these medicines are taken with Paxil. You must wait at least 14 days after stopping an MAO inhibitor before you can take Paxil. After you stop taking Paxil, you must wait at least 14 days before you start taking an MAOI.

Before taking Paxil, tell your doctor if you are allergic to any drugs, or if you have:

* liver or kidney disease;
* a bleeding or blood clotting disorder;
* seizures or epilepsy; or
* bipolar disorder (manic depression), or a history of drug abuse or suicidal thoughts.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use this medication.

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category D. Paxil may cause heart defects or serious, life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking Paxil, do not stop taking the medication without first talking to your doctor. Paxil can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* fast, pounding, or uneven heart rate;
* chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
* sudden numbness or weakness, especially on one side of the body;
* sudden headache, confusion, problems with vision, speech, or balance;
* confusion, hallucinations, or seizure (convulsions);
* easy bruising or bleeding, unusual weakness;
* restless muscle movements in your eyes, tongue, jaw, or neck;
* tremors;
* extreme thirst with headache, nausea, vomiting, and weakness;
* feeling light-headed or fainting; or
* urinating less than usual or not at all.

Less serious side effects may include:

* nausea, vomiting, stomach pain, loss of appetite;
* constipation or diarrhea;
*  weight changes;
* dry mouth, unpleasant taste;
* weakness, lack of coordination;
* numbness or tingly feeling;
* blurred vision, headache, ringing in your ears;
* mild skin rash;
* breast swelling (in men or women); or
* increased sweating.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* fast, pounding, or uneven heart rate, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
* sudden numbness or weakness, especially on one side of the body;
* sudden headache, confusion, problems with vision, speech, or balance;
* hallucinations, or seizures (convulsions), feeling light-headed, fainting;
* restless muscle movements in your eyes, tongue, jaw, or neck, uncontrollable shaking or tremor;
* skin rash, severe tingling, numbness, pain, muscle weakness;
* easy bruising or bleeding;
* extreme thirst with headache, nausea, vomiting, and weakness; or
* urinating less than usual or not at all.

Less serious side effects may include:

* nausea, vomiting, constipation, diarrhea, loss of appetite;
* dry mouth, unpleasant taste;
* feeling dizzy, drowsy, or tired;
* trouble concentrating;
* nightmares;
* blurred vision, headache, ringing in your ears;
* breast swelling (in men or women); or
* decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse: mood changes, anxiety, panic attacks, trouble sleeping, irritability, agitation, aggressiveness, severe restlessness, mania (mental and/or physical hyperactivity), thoughts of suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* increased blood pressure (severe headache, blurred vision);
* nausea, vomiting, diarrhea, fever, fast heartbeat; hallucinations, loss of coordination, fainting, coma;
* seizure (convulsions);
* extreme thirst with headache, nausea, vomiting, and weakness; or
* easy bruising or bleeding.

Less serious side effects may include:

* drowsiness, dizziness, nervousness, or anxiety;
* dry mouth, increased sweating;
* nausea, vomiting, diarrhea, constipation;
* decreased sex drive, impotence, or difficulty having an orgasm;
* headache, blurred vision;
* tremor or chills; or
* changes in appetite or weight.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
* restlessness, overactive reflexes, hallucinations, loss of coordination, fainting, coma;
* nausea, vomiting, diarrhea, fever, and fast heartbeat;
* painful or difficult urination;
*  easy bruising or bleeding, nosebleeds, or
* black, bloody, or tarry stools.

Less serious side effects may include:

* dry mouth;
* drowsiness, dizziness, headache;
* diarrhea, constipation;
* sleep problems (insomnia);
* weight changes;
* feeling anxious or nervous, increased sweating; or
* decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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Do not use Cymbalta together with thioridazine (Mellaril), or an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam). Serious and sometimes fatal reactions can occur when these medicines are taken with Cymbalta. You must wait at least 14 days after stopping an MAO inhibitor before you can take Cymbalta. After you stop taking Cymbalta, you must wait at least 5 days before you start taking an MAOI. Do not use this medication if you are allergic to Cymbalta, or if you have untreated or uncontrolled glaucoma.

Before taking Cymbalta, tell your doctor if you are allergic to any drugs, or if you have:

* liver or kidney disease;
* seizures or epilepsy;
* a bleeding or blood clotting disorder;
* glaucoma;
* bipolar disorder (manic depression); or
* a history of drug abuse or suicidal thoughts.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Cymbalta.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. Cymbalta may be harmful to an unborn baby, and may cause problems in a newborn baby if the mother takes the medication late in pregnancy (during the third trimester). Tell your doctor if you are pregnant or plan to become pregnant during treatment. Cymbalta can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the side effects of this medication. Do not give Cymbalta to anyone younger than 18 years old without the advice of a doctor.

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

* chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
* sudden numbness or weakness, especially on one side of the body;
* sudden headache, confusion, problems with vision, speech, or balance;
* feeling light-headed, fainting;
* fever, confusion, muscle stiffness, sweating, fast or uneven heartbeats;
* pale skin, easy bruising or bleeding, unusual weakness; or
* urinating more than usual.

Less serious side effects may be more likely to occur, such as:

* nausea, vomiting, stomach pain, loss of appetite, constipation or diarrhea;
* dry mouth, unpleasant taste;
* increased appetite, weight changes;
* feeling anxious, restless, dizzy, drowsy, or tired;
* blurred vision, trouble concentrating;
* sleep problems (insomnia), nightmares;
* blurred vision;
* increased sweating; or
* decreased sex drive, impotence, or difficulty having an orgasm.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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